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Prereplicative complexes assembled in vitro support origin-dependent and independent DNA replication
Eukaryotic DNA replication initiates from multiple replication origins. To ensure each origin fires just once per cell cycle, initiation is divided into two biochemically discrete steps: the Mcm2-7 helicase is first loaded into prereplicative complexes (pre-RCs) as an inactive double hexamer by the...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Publishing Ltd
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3989654/ https://ncbi.nlm.nih.gov/pubmed/24566989 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embj.201387369 |
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