β-arrestin-1 mediates the TCR-triggered re-routing of distal receptors to the immunological synapse by a PKC-mediated mechanism

T-cell receptors (TCR) recognize their antigen ligand at the interface between T cells and antigen-presenting cells, known as the immunological synapse (IS). The IS provides a means of sustaining the TCR signal which requires the continual supply of new TCRs. These are endocytosed and redirected fro...

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Detalhes bibliográficos
Main Authors: Fernández-Arenas, Elena, Calleja, Enrique, Martínez-Martín, Nadia, Gharbi, Severine I, Navajas, Rosana, García-Medel, Noel, Penela, Petronila, Alcamí, Antonio, Mayor, Federico, Albar, Juan P, Alarcón, Balbino
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989651/
https://ncbi.nlm.nih.gov/pubmed/24502978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embj.201386022
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