Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control

Mitochondrial dysfunction has long been associated with Parkinson's disease (PD). Parkin and PINK1, two genes associated with familial PD, have been implicated in the degradation of depolarized mitochondria via autophagy (mitophagy). Here, we describe the involvement of parkin and PINK1 in a ve...

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Detaylı Bibliyografya
Asıl Yazarlar: McLelland, Gian-Luca, Soubannier, Vincent, Chen, Carol X, McBride, Heidi M, Fon, Edward A
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BlackWell Publishing Ltd 2014
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989637/
https://ncbi.nlm.nih.gov/pubmed/24446486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embj.201385902
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