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Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control
Mitochondrial dysfunction has long been associated with Parkinson's disease (PD). Parkin and PINK1, two genes associated with familial PD, have been implicated in the degradation of depolarized mitochondria via autophagy (mitophagy). Here, we describe the involvement of parkin and PINK1 in a ve...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BlackWell Publishing Ltd
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3989637/ https://ncbi.nlm.nih.gov/pubmed/24446486 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embj.201385902 |
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