Pioglitazone inhibits HIF-1α-dependent angiogenesis in rats by paracrine and direct effects on endothelial cells

ABSTRACT: Pioglitazone was associated with increased hazard for surgical or percutaneous lower extremity revascularization in patients with diabetes in a large clinical trial, but this clinical finding has not been adequately explored in animal models. We hypothesized that pioglitazone would decreas...

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Autores principales: Dromparis, Peter, Sutendra, Gopinath, Paulin, Roxane, Proctor, Spencer, Michelakis, Evangelos D., McMurtry, M. Sean
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer Berlin Heidelberg 2014
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989538/
https://ncbi.nlm.nih.gov/pubmed/24408111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-013-1115-0
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