Cholesterol regulates HERG K(+) channel activation by increasing phospholipase C β1 expression

Human ether-a-go-go-related gene (HERG) K(+) channel underlies the rapidly activating delayed rectifier K(+) conductance (I(Kr)) during normal cardiac repolarization. Also, it may regulate excitability in many neuronal cells. Recently, we showed that enrichment of cell membrane with cholesterol inhi...

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Bibliographische Detailangaben
Hauptverfasser: Chun, Yoon Sun, Oh, Hyun Geun, Park, Myoung Kyu, Cho, Hana, Chung, Sungkwon
Format: Artigo
Sprache:Inglês
Veröffentlicht: Landes Bioscience 2013
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989356/
https://ncbi.nlm.nih.gov/pubmed/23793622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/chan.25122
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