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Activity-Dependent Dendritic Spine Shrinkage and Growth Involve Downregulation of Cofilin via Distinct Mechanisms

A current model posits that cofilin-dependent actin severing negatively impacts dendritic spine volume. Studies suggested that increased cofilin activity underlies activity-dependent spine shrinkage, and that reduced cofilin activity induces activity-dependent spine growth. We suggest instead that b...

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Detalhes bibliográficos
Main Authors: Calabrese, Barbara, Saffin, Jean-Michel, Halpain, Shelley
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989342/
https://ncbi.nlm.nih.gov/pubmed/24740405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094787
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