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Isoflurane Reversibly Destabilizes Hippocampal Dendritic Spines by an Actin-Dependent Mechanism

General anesthetics produce a reversible coma-like state through modulation of excitatory and inhibitory synaptic transmission. Recent evidence suggests that anesthetic exposure can also lead to sustained cognitive dysfunction. However, the subcellular effects of anesthetics on the structure of esta...

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Detalhes bibliográficos
Main Authors: Platholi, Jimcy, Herold, Karl F., Hemmings, Hugh C., Halpain, Shelley
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4113311/
https://ncbi.nlm.nih.gov/pubmed/25068870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0102978
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