Activation of lung p53 by Nutlin-3a prevents and reverses experimental pulmonary hypertension

BACKGROUND: Induction of cellular senescence through activation of the p53 tumor suppressor protein is a new option for treating proliferative disorders. Nutlins prevent the ubiquitin ligase MDM2 (murine double minute 2), a negative p53 regulator, from interacting with p53. We hypothesized that cell...

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Main Authors: Mouraret, Nathalie, Marcos, Elisabeth, Abid, Shariq, Gary-Bobo, Guillaume, Saker, Mirna, Houssaini, Amal, Dubois-Rande, Jean-Luc, Boyer, Laurent, Boczkowski, Jorge, Derumeaux, Geneviève, Amsellem, Valérie, Adnot, Serge
Format: Artigo
Sprog:Inglês
Udgivet: Lippincott Williams & Wilkins 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989211/
https://ncbi.nlm.nih.gov/pubmed/23513067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.113.002434
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