Regulatory B Cells Inhibit Cytotoxic T Lymphocyte (CTL) Activity and Elimination of Infected CD4 T Cells after In Vitro Reactivation of HIV Latent Reservoirs

During HIV infection, IL-10/IL-10 receptor and programmed death-1 (PD-1)/programmed death-1-ligand (PD-L1) interactions have been implicated in the impairment of cytotoxic T lymphocyte (CTL) activity. Despite antiretroviral therapy (ART), attenuated anti-HIV CTL functions present a major hurdle towa...

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Detalhes bibliográficos
Main Authors: Siewe, Basile, Wallace, Jennillee, Rygielski, Sonya, Stapleton, Jack T., Martin, Jeffrey, Deeks, Steven G., Landay, Alan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989168/
https://ncbi.nlm.nih.gov/pubmed/24739950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092934
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