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PolyQ Disease: Too Many Q’s, Too Much Function?
The nature of the gain-of-function toxicity found in polyglutamine (polyQ) diseases has been the subject of considerable debate. Duvick et al. (2010) and Nedelsky et al. (2010) now show that in two of these diseases, pathology is mediated by normal protein activity.
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| Asıl Yazarlar: | , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2010
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3989162/ https://ncbi.nlm.nih.gov/pubmed/20869586 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2010.09.012 |
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