Widespread RNA metabolism impairment in sporadic inclusion body myositis TDP43-proteinopathy()

TDP43 protein mislocalization is a hallmark of the neurodegenerative diseases amyotrophic lateral sclerosis and frontotemporal dementia, and mutations in the gene encoding TDP43 cause both disorders, further highlighting its role in disease pathogenesis. TDP43 is a heterogenous ribonucleoprotein, th...

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Bibliographische Detailangaben
Hauptverfasser: Cortese, Andrea, Plagnol, Vincent, Brady, Stefen, Simone, Roberto, Lashley, Tammaryn, Acevedo-Arozena, Abraham, de Silva, Rohan, Greensmith, Linda, Holton, Janice, Hanna, Michael G., Fisher, Elizabeth M.C., Fratta, Pietro
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2014
Schlagworte:
Regular Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3988933/
https://ncbi.nlm.nih.gov/pubmed/24462217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2013.12.029
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