Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies

Accumulation of hyperphosphorylated, ubiquitinated and N-terminally truncated TAR DNA-binding protein (TDP-43) is the pathological hallmark lesion in most familial and sporadic forms of FTLD-U and ALS, which can be subsumed as TDP-43 proteinopathies. In order to get more insight into the role of abn...

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Hauptverfasser: Neumann, Manuela, Kwong, Linda K., Lee, Edward B., Kremmer, Elisabeth, Flatley, Andrew, Xu, Yan, Forman, Mark, Troost, Dirk, Kretzschmar, Hans A., Trojanowski, John Q., Lee, Virginia M.-Y.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2693625/
https://ncbi.nlm.nih.gov/pubmed/19125255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-008-0477-9
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