Assisted protein folding at low temperature: evolutionary adaptation of the Antarctic fish chaperonin CCT and its client proteins

Eukaryotic ectotherms of the Southern Ocean face energetic challenges to protein folding assisted by the cytosolic chaperonin CCT. We hypothesize that CCT and its client proteins (CPs) have co-evolved molecular adaptations that facilitate CCT–CP interaction and the ATP-driven folding cycle at low te...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Cuellar, Jorge, Yébenes, Hugo, Parker, Sandra K., Carranza, Gerardo, Serna, Marina, Valpuesta, José María, Zabala, Juan Carlos, Detrich, H. William
Format: Artigo
Langue:Inglês
Publié: The Company of Biologists 2014
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3988795/
https://ncbi.nlm.nih.gov/pubmed/24659247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.20147427
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