Assisted protein folding at low temperature: evolutionary adaptation of the Antarctic fish chaperonin CCT and its client proteins

Eukaryotic ectotherms of the Southern Ocean face energetic challenges to protein folding assisted by the cytosolic chaperonin CCT. We hypothesize that CCT and its client proteins (CPs) have co-evolved molecular adaptations that facilitate CCT–CP interaction and the ATP-driven folding cycle at low te...

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Detalhes bibliográficos
Main Authors: Cuellar, Jorge, Yébenes, Hugo, Parker, Sandra K., Carranza, Gerardo, Serna, Marina, Valpuesta, José María, Zabala, Juan Carlos, Detrich, H. William
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3988795/
https://ncbi.nlm.nih.gov/pubmed/24659247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.20147427
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