Inhibition of autophagy enhances the effects of the AKT inhibitor MK-2206 when combined with paclitaxel and carboplatin in BRAF wild-type melanoma

This study investigates the mechanism of action behind the long-term responses (12–16 months) of two BRAF WT melanoma patients to the AKT inhibitor MK-2206 in combination with paclitaxel and carboplatin. Although single agent MK-2206 inhibited phospho-AKT signaling, it did not impact in vitro melano...

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Main Authors: Rebecca, Vito W., Massaro, Renato R., Fedorenko, Inna V., Sondak, Vernon K., Anderson, Alexander R.A., Kim, Eunjung, Amavaradi, Ravi K., Maria-Engler, Silvya Stuchi, Messina, Jane L., Gibney, Geoffrey T., Kudchadkar, Ragini R., Smalley, Keiran S. M.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3988257/
https://ncbi.nlm.nih.gov/pubmed/24490764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/pcmr.12227
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