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Relation of clinical culture method to T cell memory status and efficacy in xenograft models of adoptive immunotherapy
BACKGROUND: Cytotoxic T lymphocytes (CTLs) modified with chimeric antigen receptors (CARs) for adoptive immunotherapy of hematologic malignancies are effective in pre-clinical models, and this efficacy has translated to success in several clinical trials. Many early trials were disappointing, due in...
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Main Authors: | , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2014
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3988256/ https://ncbi.nlm.nih.gov/pubmed/24439255 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcyt.2013.10.013 |
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