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Relation of clinical culture method to T cell memory status and efficacy in xenograft models of adoptive immunotherapy

BACKGROUND: Cytotoxic T lymphocytes (CTLs) modified with chimeric antigen receptors (CARs) for adoptive immunotherapy of hematologic malignancies are effective in pre-clinical models, and this efficacy has translated to success in several clinical trials. Many early trials were disappointing, due in...

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Detalhes bibliográficos
Main Authors: Barrett, David M., Singh, Nathan, Liu, Xiaojun, Jiang, Shuguang, June, Carl H., Grupp, Stephan A., Zhao, Yangbing
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3988256/
https://ncbi.nlm.nih.gov/pubmed/24439255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcyt.2013.10.013
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