A Unique Human Mycoplasma Protein that Generically Blocks Antigen-Antibody Union

We report the discovery and crystal structure of a human mycoplasma protein, Protein M, which binds with high affinity to antibodies, predominantly through attachment to the variable region of the κ and λ light chains. Protein M broadly blocks antibody-antigen union and its mechanism of inhibition i...

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Detalhes bibliográficos
Main Authors: Grover, Rajesh K., Zhu, Xueyong, Nieusma, Travis, Jones, Teresa, Boreo, Isabel, MacLeod, Amanda S., Mark, Adam, Niessen, Sherry, Kim, Helen J., Kong, Leopold, Assad-Garcia, Nacyra, Kwon, Keehwan, Chesi, Marta, Smider, Vaughn V., Salomon, Daniel R., Jelinek, Diane F., Kyle, Robert A., Pyles, Richard B., Glass, John I., Ward, Andrew B., Wilson, Ian A., Lerner, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3987992/
https://ncbi.nlm.nih.gov/pubmed/24503852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1246135
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