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Induced pluripotent stem cells generated without viral integration
Pluripotent stem cells have been generated from mouse and human somatic cells by viral expression of the transcription factors Oct4, Sox2, Klf4, and c-Myc. A major limitation of this technology is the use of potentially harmful genome-integrating viruses. Here, we generate mouse induced pluripotent...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3987909/ https://ncbi.nlm.nih.gov/pubmed/18818365 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1162494 |
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