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Induced pluripotent stem cells generated without viral integration

Pluripotent stem cells have been generated from mouse and human somatic cells by viral expression of the transcription factors Oct4, Sox2, Klf4, and c-Myc. A major limitation of this technology is the use of potentially harmful genome-integrating viruses. Here, we generate mouse induced pluripotent...

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Detalhes bibliográficos
Main Authors: Stadtfeld, Matthias, Nagaya, Masaki, Utikal, Jochen, Weir, Gordon, Hochedlinger, Konrad
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3987909/
https://ncbi.nlm.nih.gov/pubmed/18818365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1162494
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