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A high efficiency system for the generation and study of human induced pluripotent stem cells

Direct reprogramming of human fibroblasts to a pluripotent state has been achieved through ectopic expression of the transcription factors OCT4, SOX2, and either cMYC and KLF4 or NANOG and LIN28. Little is known, however, about the mechanisms by which reprogramming occurs, which is in part limited b...

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Détails bibliographiques
Auteurs principaux: Maherali, Nimet, Ahfeldt, Tim, Rigamonti, Alessandra, Utikal, Jochen, Cowan, Chad, Hochedlinger, Konrad
Format: Artigo
Langue:Inglês
Publié: 2008
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3987901/
https://ncbi.nlm.nih.gov/pubmed/18786420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2008.08.003
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