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Simplified Cyclic Analogs of Bastadin-5. Structure Activity Relationships for Modulation of the RyR1/FKBP12 Ca(2+) Channel Complex
Bastadin-5, a brominated macro-dilactam from the marine sponge Ianthella basta, enhances release of Ca(2+) from stores within the sarcoplasmic reticulum (SR) of muscle and non-muscle cells by modulating RyR1/FKBP12 complex. Analogs of bastadin-5 present desirable targets for SAR studies to shed ligh...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3987770/ https://ncbi.nlm.nih.gov/pubmed/16854055 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm050708u |
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