A Novel Susceptibility Locus on Rat Chromosome 8 Affects Spontaneous but Not Experimentally Induced Type 1 Diabetes

OBJECTIVE: The biobreeding diabetes-prone (BBDP) rat spontaneously develops type 1 diabetes. Two of the genetic factors contributing to this syndrome are the major histocompatibility complex (Iddm1) and a Gimap5 mutation (Iddm2) responsible for a T-lymphopenia. Susceptibility to experimentally induc...

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Main Authors: Wallis, Robert H., Wang, KeSheng, Dabrowski, Dominika, Marandi, Leili, Ning, Terri, Hsieh, Eugene, Paterson, Andrew D., Mordes, John P., Blankenhorn, Elisabeth P., Poussier, Philippe
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3987115/
https://ncbi.nlm.nih.gov/pubmed/17389329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db06-1790
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