Type 1 Diabetes in the BB Rat: A Polygenic Disease

OBJECTIVE: Two type 1 diabetes susceptibility genes have been identified in the spontaneously diabetic biobreeding diabetes-prone (BBDP) rat, the major histocompatibility complex (MHC) (RT1) class II u haplotype (Iddm1) and Gimap5 (Iddm2). The strong effects of these have impeded previous efforts to...

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Detalhes bibliográficos
Main Authors: Wallis, Robert H., Wang, KeSheng, Marandi, Leili, Hsieh, Eugene, Ning, Terri, Chao, Gary Y.C., Sarmiento, Janice, Paterson, Andrew D., Poussier, Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2009
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2661594/
https://ncbi.nlm.nih.gov/pubmed/19168599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-1215
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