8-oxoguanine causes spontaneous de novo germline mutations in mice

Spontaneous germline mutations generate genetic diversity in populations of sexually reproductive organisms, and are thus regarded as a driving force of evolution. However, the cause and mechanism remain unclear. 8-oxoguanine (8-oxoG) is a candidate molecule that causes germline mutations, because i...

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Detalhes bibliográficos
Main Authors: Ohno, Mizuki, Sakumi, Kunihiko, Fukumura, Ryutaro, Furuichi, Masato, Iwasaki, Yuki, Hokama, Masaaki, Ikemura, Toshimichi, Tsuzuki, Teruhisa, Gondo, Yoichi, Nakabeppu, Yusaku
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986730/
https://ncbi.nlm.nih.gov/pubmed/24732879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep04689
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