CD4(+) T-cell epitopes associated with antibody responses after intravenously and subcutaneously applied human FVIII in humanized hemophilic E17 HLA-DRB1*1501 mice

Today it is generally accepted that B cells require cognate interactions with CD4(+) T cells to develop high-affinity antibodies against proteins. CD4(+) T cells recognize peptides (epitopes) presented by MHC class II molecules that are expressed on antigen-presenting cells. Structural features of b...

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Main Authors: Steinitz, Katharina N., van Helden, Pauline M., Binder, Brigitte, Wraith, David C., Unterthurner, Sabine, Hermann, Corinna, Schuster, Maria, Ahmad, Rafi U., Weiller, Markus, Lubich, Christian, de la Rosa, Maurus, Schwarz, Hans Peter, Reipert, Birgit M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986681/
https://ncbi.nlm.nih.gov/pubmed/22394599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-08-374645
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