Targeted deletion of the C-terminus of the mouse adenomatous polyposis coli tumor suppressor results in neurologic phenotypes related to schizophrenia

BACKGROUND: Loss of adenomatous polyposis coli (APC) gene function results in constitutive activation of the canonical Wnt pathway and represents the main initiating and rate-limiting event in colorectal tumorigenesis. APC is likely to participate in a wide spectrum of biological functions via its d...

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Autors principals: Onouchi, Takanori, Kobayashi, Katsunori, Sakai, Kazuyoshi, Shimomura, Atsushi, Smits, Ron, Sumi-Ichinose, Chiho, Kurosumi, Masafumi, Takao, Keizo, Nomura, Ryuji, Iizuka-Kogo, Akiko, Suzuki, Hidenori, Kondo, Kazunao, Akiyama, Tetsu, Miyakawa, Tsuyoshi, Fodde, Riccardo, Senda, Takao
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2014
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986642/
https://ncbi.nlm.nih.gov/pubmed/24678719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-6606-7-21
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