PI3K/Akt-Independent NOS/HO Activation Accounts for the Facilitatory Effect of Nicotine on Acetylcholine Renal Vasodilations: Modulation by Ovarian Hormones

We investigated the effect of chronic nicotine on cholinergically-mediated renal vasodilations in female rats and its modulation by the nitric oxide synthase (NOS)/heme oxygenase (HO) pathways. Dose-vasodilatory response curves of acetylcholine (0.01–2.43 nmol) were established in isolated phenyleph...

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Detalhes bibliográficos
Main Authors: Gohar, Eman Y., El-gowilly, Sahar M., El-Gowelli, Hanan M., El-Demellawy, Maha A., El-Mas, Mahmoud M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986343/
https://ncbi.nlm.nih.gov/pubmed/24733557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0095079
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