Glycogen synthase kinase 3 inhibitors induce the canonical WNT/β-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma

Embryonal rhabdomyosarcoma (ERMS) is a common pediatric malignancy of muscle, with relapse being the major clinical challenge. Self-renewing tumor-propagating cells (TPCs) drive cancer relapse and are confined to a molecularly definable subset of ERMS cells. To identify drugs that suppress ERMS self...

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Detalhes bibliográficos
Main Authors: Chen, Eleanor Y., DeRan, Michael T., Ignatius, Myron S., Grandinetti, Kathryn Brooke, Clagg, Ryan, McCarthy, Karin M., Lobbardi, Riadh M., Brockmann, Jillian, Keller, Charles, Wu, Xu, Langenau, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986146/
https://ncbi.nlm.nih.gov/pubmed/24706870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1317731111
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