Vangl2/RhoA Signaling Pathway Regulates Stem Cell Self-Renewal Programs and Growth in Rhabdomyosarcoma

Tumor growth and relapse are driven by tumor propagating cells (TPCs). However, mechanisms regulating TPC fate choices, maintenance, and self-renewal are not fully understood. Here, we show that Van Gogh-like 2 (Vangl2), a core regulator of the non-canonical Wnt/planar cell polarity (Wnt/PCP) pathwa...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Hayes, Madeline N., McCarthy, Karin, Jin, Alexander, Oliveira, Mariana L., Iyer, Sowmya, Garcia, Sara P., Sindiri, Sivasish, Gryder, Berkley, Motala, Zainab, Petur Nielsen, G., Borg, Jean-Paul, van de Rijn, Matt, Malkin, David, Khan, Javed, Ignatius, Myron S., Langenau, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6354590/
https://ncbi.nlm.nih.gov/pubmed/29499154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2018.02.002
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