Nkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors

Loss of functional β-cell mass is a hallmark of type 1 and type 2 diabetes, and methods for restoring these cells are needed. We have previously reported that overexpression of the homeodomain transcription factor NK6 homeobox 1 (Nkx6.1) in rat pancreatic islets induces β-cell proliferation and enha...

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Detalhes bibliográficos
Main Authors: Tessem, Jeffery S., Moss, Larry G., Chao, Lily C., Arlotto, Michelle, Lu, Danhong, Jensen, Mette V., Stephens, Samuel B., Tontonoz, Peter, Hohmeier, Hans E., Newgard, Christopher B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986138/
https://ncbi.nlm.nih.gov/pubmed/24706823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1320953111
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