The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells

We have previously described rat insulinoma INS-1-derived cell lines with robust or poor glucose-stimulated insulin secretion (GSIS). In the current study, we have further resolved these lines into three classes: class 1, glucose-unresponsive/glucagon-expressing; class 2, glucose-unresponsive/glucag...

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Bibliografiske detaljer
Main Authors: Schisler, Jonathan C., Jensen, Per Bo, Taylor, David G., Becker, Thomas C., Knop, Filip Krag, Takekawa, Shiro, German, Michael, Weir, Gordon C., Lu, Danhong, Mirmira, Raghavendra G., Newgard, Christopher B.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2005
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1091752/
https://ncbi.nlm.nih.gov/pubmed/15883383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0502168102
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