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IGF2 Ameliorates Amyloidosis, Increases Cholinergic Marker Expression and Raises BMP9 and Neurotrophin Levels in the Hippocampus of the APPswePS1dE9 Alzheimer’s Disease Model Mice

The development of an effective therapy for Alzheimer’s disease (AD) is a major challenge to biomedical sciences. Because much of early AD pathophysiology includes hippocampal abnormalities, a viable treatment strategy might be to use trophic factors that support hippocampal integrity and function....

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Détails bibliographiques
Auteurs principaux: Mellott, Tiffany J., Pender, Sarah M., Burke, Rebecca M., Langley, Erika A., Blusztajn, Jan Krzysztof
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986048/
https://ncbi.nlm.nih.gov/pubmed/24732467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094287
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