Structure and Inhibition of Tuberculosinol Synthase and Decaprenyl Diphosphate Synthase from Mycobacterium tuberculosis

[Image: see text] We have obtained the structure of the bacterial diterpene synthase, tuberculosinol/iso-tuberculosinol synthase (Rv3378c) from Mycobacterium tuberculosis, a target for anti-infective therapies that block virulence factor formation. This phosphatase adopts the same fold as found in t...

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Hauptverfasser: Chan, Hsiu-Chien, Feng, Xinxin, Ko, Tzu-Ping, Huang, Chun-Hsiang, Hu, Yumei, Zheng, Yingying, Bogue, Shannon, Nakano, Chiaki, Hoshino, Tsutomu, Zhang, Lilan, Lv, Pin, Liu, Wenting, Crick, Dean C., Liang, Po-Huang, Wang, Andrew H.-J., Oldfield, Eric, Guo, Rey-Ting
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2014
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986019/
https://ncbi.nlm.nih.gov/pubmed/24475925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja413127v
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