Strictly Conserved Lysine of Prolyl-tRNA Synthetase Editing Domain Facilitates Binding and Positioning of Misacylated tRNA(Pro)

[Image: see text] To ensure high fidelity in translation, many aminoacyl-tRNA synthetases, enzymes responsible for attaching specific amino acids to cognate tRNAs, require proof-reading mechanisms. Most bacterial prolyl-tRNA synthetases (ProRSs) misactivate alanine and employ a post-transfer editing...

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Main Authors: Bartholow, Thomas G., Sanford, Brianne L., Cao, Bach, Schmit, Heidi L., Johnson, James M., Meitzner, Jet, Bhattacharyya, Sudeep, Musier-Forsyth, Karin, Hati, Sanchita
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2014
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986007/
https://ncbi.nlm.nih.gov/pubmed/24450765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi401279r
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