Decoy Plasminogen Receptor Containing a Selective Kunitz-Inhibitory Domain

[Image: see text] Kunitz domain 1 (KD1) of tissue factor pathway inhibitor-2 in which P2′ residue Leu17 (bovine pancreatic trypsin inhibitor numbering) is mutated to Arg selectively inhibits the active site of plasmin with ∼5-fold improved affinity. Thrombin cleavage (24 h extended incubation at a 1...

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Detalhes bibliográficos
Main Authors: Kumar, Yogesh, Vadivel, Kanagasabai, Schmidt, Amy E., Ogueli, Godwin I., Ponnuraj, Sathya M., Rannulu, Nalaka, Loo, Joseph A., Bajaj, Madhu S., Bajaj, S. Paul
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985851/
https://ncbi.nlm.nih.gov/pubmed/24383758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi401584b
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