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High Temperature SELMA: Evolution of DNA-Supported Oligomannose Clusters Which Are Tightly Recognized by HIV bnAb 2G12

[Image: see text] SELMA (SELection with Modified Aptamers) is a directed evolution method which can be used to develop DNA-supported clusters of carbohydrates in which the geometry of clustering is optimized for strong recognition by a lectin of interest. Herein, we report a modification of SELMA wh...

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Autors principals: Temme, J. Sebastian, MacPherson, Iain S., DeCourcey, John F., Krauss, Isaac J.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2014
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985446/
https://ncbi.nlm.nih.gov/pubmed/24446826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja411212q
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