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Assessing the subcellular distribution of oncogenic phosphoinositide 3-kinase using microinjection into live cells
Oncogenic mutations in PIK3CA lead to an increase in intrinsic phosphoinositide kinase activity, but it is thought that increased access of PI3Kα (phosphoinositide 3-kinase α) to its PM (plasma membrane) localized substrate is also required for increased levels of downstream PIP(3)/Akt [phosphoinosi...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Portland Press Ltd.
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3985441/ https://ncbi.nlm.nih.gov/pubmed/27919038 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20130133 |
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