The Marburg virus VP24 protein interacts with Keap1 to activate the cytoprotective antioxidant response pathway

Kelch-like ECH-associated protein 1 (Keap1) is an ubiquitin E3 ligase specificity factor that targets transcription factor Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) for ubiquitination and degradation. Disrupting Keap1-Nrf2 interaction stabilizes Nrf2; resulting in Nrf2 nuclear accumulation,...

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Detalhes bibliográficos
Main Authors: Edwards, Megan R., Johnson, Britney, Mire, Chad E., Xu, Wei, Shabman, Reed S., Speller, Lauren N., Leung, Daisy W., Geisbert, Thomas W., Amarasinghe, Gaya K., Basler, Christopher F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985291/
https://ncbi.nlm.nih.gov/pubmed/24630991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.01.043
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