Variation in P450 oxidoreductase (POR) A503V and flavin containing monooxygenase (FMO)-3 E158K is associated with minor alterations in nicotine metabolism but does not alter cigarette consumption

Nicotine metabolism rates differ widely, even after controlling for genetic variation in the major nicotine metabolizing enzyme, CYP2A6. Genetic variants in an additional nicotine metabolizing enzyme, flavin containing monooxygenase (FMO)-3, and an obligate microsomal CYP-supportive enzyme, cytochro...

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Huvudupphovsmän: Chenoweth, Meghan J., Zhu, Andy Z. X., Cox, Lisa Sanderson, Ahluwalia, Jasjit S., Benowitz, Neal L., Tyndale, Rachel F.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985268/
https://ncbi.nlm.nih.gov/pubmed/24448396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0000000000000031
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