Elucidating heterogeneity of IgA1 hinge-region O-glycosylation by use of MALDI-TOF/TOF mass spectrometry: role of cysteine alkylation during sample processing

Determining disease-associated changes in protein glycosylation provides a better understanding of pathogenesis. This work focuses on human immunoglobulin A1 (IgA1), where aberrant O-glycosylation plays a key role in the pathogenesis of IgA nephropathy (IgAN). Normal IgA1 hinge region carries 3 to 6...

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Detaylı Bibliyografya
Asıl Yazarlar: Franc, Vojtěch, Řehulka, Pavel, Raus, Martin, Stulík, Jiří, Novak, Jan, Renfrow, Matthew B., Šebela, Marek
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3984899/
https://ncbi.nlm.nih.gov/pubmed/23891555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jprot.2013.07.013
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