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Synthesis and Gene Silencing Properties of siRNAs Containing Terminal Amide Linkages
The active components of the RNAi are 21 nucleotides long dsRNAs containing a 2 nucleotide overhang at the 3′ end, carrying 5′-phosphate and 3′-hydroxyl groups (siRNAs). Structural analysis revealed that the siRNA is functionally bound at both ends to RISC. Terminal modifications are considered with...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Hindawi Publishing Corporation
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3984766/ https://ncbi.nlm.nih.gov/pubmed/24791003 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/901617 |
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