Lactate dehydrogenase A silencing in IDH mutant gliomas

BACKGROUND: Mutations of the isocitrate dehydrogenase 1 and 2 gene (IDH1/2) were initially thought to enhance cancer cell survival and proliferation by promoting the Warburg effect. However, recent experimental data have shown that production of 2-hydroxyglutarate by IDH mutant cells promotes hypoxi...

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Détails bibliographiques
Auteurs principaux: Chesnelong, Charles, Chaumeil, Myriam M., Blough, Michael D., Al-Najjar, Mohammad, Stechishin, Owen D., Chan, Jennifer A., Pieper, Russell O., Ronen, Sabrina M., Weiss, Samuel, Luchman, H. Artee, Cairncross, J. Gregory
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2014
Sujets:
Basic and Translational Investigations
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3984548/
https://ncbi.nlm.nih.gov/pubmed/24366912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/not243
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