An in vivo patient-derived model of endogenous IDH1-mutant glioma

Somatic mutations in the catalytic domain of isocitrate dehydrogenase (IDH) 1/2 and accumulation of the oncometabolite 2-hydroxyglutarate (2-HG) appear to be among the earliest events in gliomagenesis and may contribute to malignant transformation. The lack of cell lines with endogenous mutations ha...

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Autori principali: Luchman, H. Artee, Stechishin, Owen D., Dang, N. Ha, Blough, Michael D., Chesnelong, Charles, Kelly, John J., Nguyen, Stephanie A., Chan, Jennifer A., Weljie, Aalim M., Cairncross, J. Gregory, Weiss, Samuel
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2012
Soggetti:
Basic and Translational Investigations
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266388/
https://ncbi.nlm.nih.gov/pubmed/22166263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nor207
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