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Conformational analysis of processivity clamps in solution demonstrates that tertiary structure does not correlate with protein dynamics

The relationship between protein sequence, structure, and dynamics has been elusive. We report one of the first comprehensive analyses using an in-solution experimental approach to study how the conservation of tertiary structure correlates with protein dynamics. Hydrogen exchange measurements of ei...

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Detalhes bibliográficos
Main Authors: Fang, Jing, Nevin, Philip, Kairys, Visvaldas, Venclovas, Česlovas, Engen, John R., Beuning, Penny J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3984358/
https://ncbi.nlm.nih.gov/pubmed/24613485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2014.02.001
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