Conformational dynamics of the Escherichia coli DNA polymerase manager proteins UmuD and UmuD′

The expression of Escherichia coli umuD gene products is upregulated as part of the SOS response to DNA damage. UmuD is initially produced as a 139-amino acid protein, which subsequently cleaves off its N-terminal 24-amino acids in a RecA/ssDNA-dependent reaction, giving UmuD′. The two forms of the...

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Main Authors: Fang, Jing, Rand, Kasper D., Silva, Michelle C., Wales, Thomas E., Engen, John R., Beuning, Penny J.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853235/
https://ncbi.nlm.nih.gov/pubmed/20206636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.02.040
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