Lorvotuzumab mertansine, a CD56-targeting antibody-drug conjugate with potent antitumor activity against small cell lung cancer in human xenograft models

Lorvotuzumab mertansine (LM) is an antibody-drug conjugate composed of a humanized anti-CD56 antibody, lorvotuzumab, linked via a cleavable disulfide linker to the tubulin-binding maytansinoid DM1. CD56 is expressed on most small cell lung cancers (SCLC), providing a promising therapeutic target for...

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Main Authors: Whiteman, Kathleen R, Johnson, Holly A, Mayo, Michele F, Audette, Charlene A, Carrigan, Christina N, LaBelle, Alyssa, Zukerberg, Lawrence, Lambert, John M, Lutz, Robert J
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3984343/
https://ncbi.nlm.nih.gov/pubmed/24492307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.27756
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