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The cyclin-dependent kinase inhibitor p57(Kip2) mediates proliferative actions of PTHrP in chondrocytes

Parathyroid hormone–related peptide (PTHrP) is a positive regulator of chondrocyte proliferation during bone development. In embryonic mice lacking PTHrP, chondrocytes stop proliferating prematurely, with accelerated differentiation. Because the bone phenotype of mice lacking the cyclin-dependent ki...

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Udgivet i:J Clin Invest
Principais autores: MacLean, Helen E., Guo, Jun, Knight, Melissa C., Zhang, Pumin, Cobrinik, David, Kronenberg, Henry M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2004
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC398433/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15124025/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI21252
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