HER2 monoclonal antibodies that do not interfere with receptor heterodimerization-mediated signaling induce effective internalization and represent valuable components for rational antibody-drug conjugate design

The human epidermal growth factor receptor (HER)2 provides an excellent target for selective delivery of cytotoxic drugs to tumor cells by antibody-drug conjugates (ADC) as has been clinically validated by ado-trastuzumab emtansine (Kadcyla(TM)). While selecting a suitable antibody for an ADC approa...

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Main Authors: de Goeij, Bart ECG, Peipp, Matthias, de Haij, Simone, van den Brink, Edward N, Kellner, Christian, Riedl, Thilo, de Jong, Rob, Vink, Tom, Strumane, Kristin, Bleeker, Wim K, Parren, Paul WHI
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
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Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3984328/
https://ncbi.nlm.nih.gov/pubmed/24492309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.27705
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